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Chemical Structure : SIK inhibitor M22
Catalog No.: PC-20809Not For Human Use, Lab Use Only.
SIK inhibitor M22 is a potent, selective pan-SIK (salt-inducible kinase) with IC50 of 72, 89 and 18 nM for SIK1, SIK2 and SIK3 in NanoBERT assays, respectively.
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SIK inhibitor M22 is a potent, selective pan-SIK (salt-inducible kinase) with IC50 of 72, 89 and 18 nM for SIK1, SIK2 and SIK3 in NanoBERT assays, respectively.
SIK inhibitor M22 displays excellent selectivity in a representative kinase panel, including STE group kinases.
SIK inhibitor M22 treatment caused centrosome dissociation and subsequent cell-cycle arrest in ovarian cancer cells, as observed with MRIA9 (Cat. PC-72723), conclusively linking these phenotypic effects to SIK inhibition.
MR22 is a valuable tool compound for studying SIK kinase function in cells.
| M.Wt | 359.38 | |
| Formula | C18H19F2N5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Rak M, et al. Eur J Med Chem. 2023 Jun 5;254:115347.
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