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Chemical Structure : SINCRO
Catalog No.: PC-35434Not For Human Use, Lab Use Only.
SINCRO is a novel anti-cancer compound that can activate the cytosolic DNA-sensing STING signaling pathway leading to the induction of type I interferon (IFN) genes.
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SINCRO is a novel anti-cancer compound that can activate the cytosolic DNA-sensing STING signaling pathway leading to the induction of type I interferon (IFN) genes。
SINCRO (STING-mediated interferon-inducing and cytotoxic reagent, original) shows a STING-independent cytotoxic activity against cancer cells, SINCRO does not evoke DNA double-strand break or caspase-3 cleavage, induces cell death in a manner different from conventional apoptosis-inducing pathways。
SINCRO significantly attenuates in vivo tumor growth by both type I IFN-dependent and independent mechanisms.
| M.Wt | 504.723 | |
| Formula | C30H44N6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kimura Y, et al. Cancer Sci. 2018 Jul 7. doi: 10.1111/cas.13726.
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