SIP0401 | PDE4B inhibitor | Probechem Biochemicals

Chemical Structure : SIP0401

SIP0401 (SIP-0401)

Catalog No.: PC-26313Not For Human Use, Lab Use Only.

SIP0401 is a potent, isoform-preferential PDE4B inhibitor with IC50 of 282 nM (PDE-Glo) and 338.4 nM (HTRF), selective for PDE4B over PDE4A/C/D (IC50=1.16-1.97 uM).

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Biological Activity

SIP0401 is a potent, isoform-preferential PDE4B inhibitor with IC50 of 282 nM (PDE-Glo) and 338.4 nM (HTRF), selective for PDE4B over PDE4A/C/D (IC50=1.16-1.97 uM).
SIP0401 induces concentration-dependent cAMP accumulation in THP-1 macrophages with EC50 of 2.52 uM.
SIP0401 dose-dependently inhibits LPS-induced TNF-α secretion in differentiated THP-1 macrophages (IC50=3.24 uM), similar to the reference PDE4 inhibitor rolipram.

Physicochemical Properties

M.Wt	376.46
Formula	C22H24N4O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(4-(4-morpholinopiperidine-1-carbonyl)phenyl)picolinonitrile

References

1. Alghamdi UM, et al. Mol Biol Rep. 2026 Mar 10;53(1):480.

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SIP0401 (SIP-0401)

Biological Activity

Physicochemical Properties

References

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