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Chemical Structure : SIS17
CAS No.: 2374313-54-7
Catalog No.: PC-72097Not For Human Use, Lab Use Only.
SIS17 is a selective, cell-active HDAC11 inhibitor with IC50 of 0.83 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $198 | In stock | |
| 100 mg | $498 | In stock | |
| 200 mg | $798 | In stock | |
| 1 g | Get quote |
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SIS17 is a selective, cell-active HDAC11 inhibitor with IC50 of 0.83 uM.
SIS17 displays no inhibitory effect (IC50>100 uM) against Class I (HDAC1 and HDAC8), Class II (HDAC4), and the NAD-dependent Class III (sirtuins, SIRT1, SIRT2, SIRT3, and SIRT6).
SIS17 inhibits the demyristoylation of a myristoyl-SHMT2 peptide by HDAC11 in vitro with IC50 of 270 nM, inhibits HDAC11-mediated SHMT2 defatty-acylation in cells.
| M.Wt | 366.608 | |
| Formula | C21H38N2OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N'-hexadecylthiophene-2-carbohydrazide |
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1. Se In Son, et al. ACS Chem Biol. 2019 Jul 19;14(7):1393-1397.
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