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SJPYT-318

Chemical Structure : SJPYT-318

CAS No.:

SJPYT-318 (SJPYT318)

Catalog No.: PC-21198Not For Human Use, Lab Use Only.

SJPYT-318 is a highly selective pregnane X receptor (PXR) agonist, targets PXR ligand-binding domain (LBD), exhibits selectivity for PXR LBD over LXR LBDs for recruiting SRC-1.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

SJPYT-318 is a highly selective pregnane X receptor (PXR) agonist, targets PXR ligand-binding domain (LBD), exhibits selectivity for PXR LBD over LXR LBDs for recruiting SRC-1.
SJPYT-318 is strongly selective for PXR in cellular reporter activation, showing only marginal activation of both LXRα and LXRβ.

Physicochemical Properties

M.Wt 581.53
Formula C28H21F6NO4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
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Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-N-(4-phenoxybenzyl)benzenesulfonamide

References

1. Huber AD, et al. Structure. 2023 Sep 5:S0969-2126(23)00297-6.

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