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SJPYT-318

Chemical Structure : SJPYT-318

CAS No.: 3114398-35-2

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SJPYT-318 (SJPYT318)

Catalog No.: PC-21198Not For Human Use, Lab Use Only.

SJPYT-318 is a highly selective pregnane X receptor (PXR) agonist, targets PXR ligand-binding domain (LBD), exhibits selectivity for PXR LBD over LXR LBDs for recruiting SRC-1.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    SJPYT-318 is a highly selective pregnane X receptor (PXR) agonist, targets PXR ligand-binding domain (LBD), exhibits selectivity for PXR LBD over LXR LBDs for recruiting SRC-1.
    SJPYT-318 is strongly selective for PXR in cellular reporter activation, showing only marginal activation of both LXRα and LXRβ.

    Physicochemical Properties

    M.Wt 581.53
    Formula C28H21F6NO4S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-N-(4-phenoxybenzyl)benzenesulfonamide

    References

    1. Huber AD, et al. Structure. 2023 Sep 5:S0969-2126(23)00297-6.

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