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Chemical Structure : SKF-96365 hydrochloride
CAS No.: 130495-35-1
Catalog No.: PC-42017Not For Human Use, Lab Use Only.
SKF-96365 hydrochloride (SKF96365) is potent inhibitor of receptor-mediated calcium entry (RMCE) with IC50 of 8.5 and 11.7 uM for inhibition in platelets stimulated with ADP and thrombin, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $198 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | $498 | In stock | |
| 250 mg | Get quote | ||
| 1 g | Get quote |
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SKF-96365 hydrochloride (SKF96365) is potent inhibitor of receptor-mediated calcium entry (RMCE) with IC50 of 8.5 and 11.7 uM for inhibition in platelets stimulated with ADP and thrombin, respectively.
SKF-96365 shows selectivity in blocking RMCE compared with receptor-mediated internal Ca2+ release.
SKF-96365 inhibits Store-operated Ca2+ entry (SOCE) and Icrac in the 20-30 uM range in several cell lines, and inhibits STIM1-mediated Ca2+ influx and the nuclear translocation and activation of the NFAT transcription factor in cells expressing STIM1.
SKF-96365 also blocks TRPC, voltage gated Ca2+ channel (human Cav3.1 IC50= 560 nM), potassium channels.
| M.Wt | 402.9144 | |
| Formula | C22H27ClN2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 30 mg/mL |
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| Chemical Name/SMILES |
1H-Imidazole, 1-[2-(4-methoxyphenyl)-2-[3-(4-methoxyphenyl)propoxy]ethyl]-, hydrochloride (1:1) |
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1. Merritt JE, et al. Biochem J. 1990 Oct 15;271(2):515-22.
2. Singh A, et al. Br J Pharmacol. 2010 Jul;160(6):1464-75.
3. Várnai P, et al. Trends Pharmacol Sci. 2009 Mar;30(3):118-28.
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