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Chemical Structure : SL-145
Catalog No.: PC-38632Not For Human Use, Lab Use Only.
SL-145 is a novel C-terminal HSP90 inhibitor, induces apoptosis in TNBC cells via the suppression of oncogenic AKT, MEK/ERK, and JAK2/STAT3 signaling.
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SL-145 is a novel C-terminal HSP90 inhibitor, induces apoptosis in TNBC cells via the suppression of oncogenic AKT, MEK/ERK, and JAK2/STAT3 signaling.
SL-145 targets the C-terminal domain of HSP90, does not trigger the heat shock response (HSR), compared to other inhibitors.
SL-145 markedly downregulated AKT, MEK, and ERK expression and reduced their phosphorylation.
SL-145 impedes tumor growth by targeting breast cancer stem cell (BCSC)-like properties in vitro and in vivo, impairs metastatic spread from primary tumors via dysregulation of STAT3 signaling.
| M.Wt | 445.515 | |
| Formula | C27H27NO5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ji Young Kim, et al. Oncogene. 2022 May 2. doi: 10.1038/s41388-022-02269-y.
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