Chemical Structure : SLL-022CCP
CAS No.:
SLL-022CCP
Catalog No.: PC-27169Not For Human Use, Lab Use Only.
SLL-022CCP is a potent, selective κ-opioid receptor (KOR) agonist with EC50 of 0.002 nM for inhibiting cAMP production, exhibits high receptor subtype selectivity over μ-opioid receptor (MOR, EC50=1.6 nM) and δ-opioid receptor (DOR, EC50=30.0 nM).
| Packing | Price | Stock | Quantity |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
SLL-022CCP is a potent, selective κ-opioid receptor (KOR) agonist with EC50 of 0.002 nM for inhibiting cAMP production, exhibits high receptor subtype selectivity over μ-opioid receptor (MOR, EC50=1.6 nM) and δ-opioid receptor (DOR, EC50=30.0 nM).
SLL-022CCP recruited β-arrestin at the KOR with an EC50 of 15.5 nM and at the MOR with an EC50 of 668.0 nM.
SLL-022CCP produced potent antinociception in the hot plate test (ED50 = 1.816 mg/kg), acetic acid-induced writhing test (ED50 = 0.113 mg/kg), and significant antipruritic effects in the histamine-induced itch test (ED50 = 0.079 mg/kg) and CFA-induced itch test (ED50 = 0.105 mg/kg).
SLL-022CCP exhibits robust antinociceptive and antipruritic effects with low central side effects.
Physicochemical Properties
|
M.Wt
|
|
|
Formula
|
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
|
Contact Us
sales@probechem.com
