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SLLN-15

Chemical Structure : SLLN-15

CAS No.:

SLLN-15 (Autophagy inducer SLLN-15)

Catalog No.: PC-36107Not For Human Use, Lab Use Only.

SLLN-15 (Autophagy inducer SLLN-15) is a potent, orally available inducer of autophagy that selectively activated cytostatic macroautophagy/autophagy in TNBC preclinical models, promotes AURKA degradation and .

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

SLLN-15 (Autophagy inducer SLLN-15) is a potent, orally available inducer of autophagy that selectively activated cytostatic macroautophagy/autophagy in TNBC preclinical models, promotes AURKA degradation and ; induced a dose-dependent anti-proliferative activity in the TNBC cell lines MDA-MB-231 and BT-20 via induction of autophagy and autophagic flux, associated with a selective inhibition of AKT-MTOR signaling; SLLN-15-induced autophagy in TNBC cells was also associated with decreased AURKA expression decreased AKT phosphorylation and subsequent blockage of the AKT-MTOR pathway; demonstrates anticancer and anti-metastatic activity in mice bearing TNBC.

Physicochemical Properties

M.Wt 507.362
Formula C19H23N7Se2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(S)-N2-(4-selenomorpholinophenyl)-N6-(tetrahydroselenophen-3-yl)-9H-purine-2,6-diamine

References

1. Chang CH, et al. Autophagy. 2019 Feb 17. doi: 10.1080/15548627.2019.1582951.

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