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SLOS-1811-06 tR1

Chemical Structure : SLOS-1811-06 tR1

CAS No.: 2797998-72-0

SLOS-1811-06 tR1

Catalog No.: PC-26889Not For Human Use, Lab Use Only.

SLOS-1811-06 tR1 is a potent, small molecule activator of NRF2 with EC50 of 0.98 nM in ARE-luciferase reporter assays, shows inhibitory activity of NRF2-KEAP1 with IC50 of 0.17 nM in BRET assays, protects hiPSC-derived RGCs from hypoxia/reoxygenation injury.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

SLOS-1811-06 tR1 is a potent, small molecule activator of NRF2 with EC50 of 0.98 nM in ARE-luciferase reporter assays, shows inhibitory activity of NRF2-KEAP1 with IC50 of 0.17 nM in BRET assays, protects hiPSC-derived RGCs from hypoxia/reoxygenation injury.

Physicochemical Properties

M.Wt 542.67
Formula C27H30N2O6S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(2R,3S)-3-(5-acetylthiophen-2-yl)-3-(3-(((R)-4-ethyl-1,1-dioxido-3,4-dihydro-2H-pyrido[4,3-b][1,4,5]oxathiazepin-2-yl)methyl)-4-methylphenyl)-2-methylpropanoic acid

References

1. Miyabe T, et al. Exp Eye Res. 2026 May 19:111078.

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