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Chemical Structure : SLP9101555
Catalog No.: PC-49075Not For Human Use, Lab Use Only.
SLP9101555 is a potent, selective sphingosine kinase SphK2 with Ki of 90 nM (hSphK2), 200-fold selectivity over SphK1.
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SLP9101555 is a potent, selective sphingosine kinase SphK2 with Ki of 90 nM (hSphK2), 200-fold selectivity over SphK1.
SLP9101555 is cell permeable and SLP9101555 (30-1000 nM) suppresses the conversion of FTY720 to FTY720-P in whole cells via inhibition of SphK2.
SLP9101555 (5 mg/kg, i.p.) elicits profound increases in blood S1P concentration in in vivo testing in mice, a pharmacodynamic index of target engagement.
| M.Wt | 435.50 | |
| Formula | C22H28F3N5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Srinath Pashikanti, et al. ACS Bio & Med Chem Au, 2022.
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