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Chemical Structure : SLU-PP-1072
Catalog No.: PC-20417Not For Human Use, Lab Use Only.
SLU-PP-1072 is a potent, selective, dual ERRα/γ inverse agonist, inhibits ERRα- and ERRγ-dependent transcription in cotransfection assays with IC50 of 4.8 and 0.9 uM.
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SLU-PP-1072 is a potent, selective, dual ERRα/γ inverse agonist, inhibits ERRα- and ERRγ-dependent transcription in cotransfection assays with IC50 of 4.8 and 0.9 uM.
SLU-PP-1072 does not inhibit ERRβ, does not display estrogen receptor activity.
SLU-PP-1072 alters PCa cell metabolism and gene expression, resulting in cell cycle dysregulation and increased apoptosis without acute mitochondrial uncoupling activity.
SLU-PP-1072 is a unique chemical tool to evaluate the pharmacology of ERRα and ERRγ.
| M.Wt | 336.37 | |
| Formula | C18H12N2O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Emmalie Schoepke, et al. ACS Chem Biol. 2020 Sep 18;15(9):2338-2345.
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