Chemical Structure : SM-06-09
CAS No.:
SM-06-09
Catalog No.: PC-26932Not For Human Use, Lab Use Only.
SM-06-09 is a highly potent, selective HDAC6 inhibitor with IC50 of 0.49 nM, displays 35-fold selectivity over HDAC10 and >100-fold over all other HDACs.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
SM-06-09 is a highly potent, selective HDAC6 inhibitor with IC50 of 0.49 nM, displays 35-fold selectivity over HDAC10 and >100-fold over all other HDACs.
SM-06-09 inhibits total deacetylase activity in the RAW264.7 murine macrophage cell line with IC50 of 1.25-2.5 uM, inhibits nearly 85% of the total HDAC activity at 10 uM.
SM-06-09 enhances macrophage phagocytosis, antigen presentation, and T-cell activation in vitro.
SM-06-09 suppresses tumor growth and promoted M1-like TAM polarization in syngeneic melanoma model.
The combination of SM-06-09 and anti-PD-1 enhances the tumor immune landscape for immune-mediated tumor killing.
Physicochemical Properties
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M.Wt
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367.33
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Formula
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C16H13N7O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-Hydroxy-5-(2-(5-oxo-4-(quinolin-3-yl)-4,5-dihydro-1H-tetrazol-1-yl)ethyl)isoxazole-3-carboxamide
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References
1. Nithya Gajendran, et al. J Med Chem. 2026 May 29. doi: 10.1021/acs.jmedchem.5c02453.
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