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SM141

Chemical Structure : SM141

CAS No.: 3023276-76-5

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SM141 (SM-141)

Catalog No.: PC-28224Not For Human Use, Lab Use Only.

SM141 is a potent, selective peptidomimetic dual inhibitor of SARS-CoV-2 main protease (MPro) and host cathepsin L (CatL) with IC50 of 0.9 uM and 0.06 uM respectively.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

SM141 is a potent, selective peptidomimetic dual inhibitor of SARS-CoV-2 main protease (MPro) and host cathepsin L (CatL) with IC50 of 0.9 uM and 0.06 uM respectively.
SM141 blocks SARS-CoV2 replication in hACE2 expressing A549 cells with IC50 of 8.2 nM.
SM141 does not inhibit the other cysteine protease, papain-like protease (PLPro) and CatL.
SM141 reduced viral replication, viral loads in the lung, and enhanced survival in SARS-CoV2 infected K18-ACE2 transgenic mice.

Physicochemical Properties

M.Wt 520.63
Formula C29H36N4O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

ethyl (S,E)-4-((S)-2-((R)-2-amino-3-phenylpropanamido)-3-phenylpropanamido)-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoate

References

1. Mondal S, et al. J Am Chem Soc. 2022 Nov 23;144(46):21035-21045.

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