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SM142

Chemical Structure : SM142

CAS No.: 3023276-79-8

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SM142 (SM-142)

Catalog No.: PC-28225Not For Human Use, Lab Use Only.

SM142 is a potent, selective peptidomimetic dual inhibitor of SARS-CoV-2 main protease (MPro) and host cathepsin L (CatL) with IC50 of 1.8 uM and 0.145 uM respectively.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

SM142 is a potent, selective peptidomimetic dual inhibitor of SARS-CoV-2 main protease (MPro) and host cathepsin L (CatL) with IC50 of 1.8 uM and 0.145 uM respectively.
SM142 blocks SARS-CoV2 replication in hACE2 expressing A549 cells with IC50 of 14.7 nM.
SM142 does not inhibit the other cysteine protease, papain-like protease (PLPro) and CatL.
SM142 reduced viral replication, viral loads in the lung, and enhanced survival in SARS-CoV2 infected K18-ACE2 transgenic mice.

Physicochemical Properties

M.Wt 638.74
Formula C34H43FN4O7
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

ethyl (6R,9S,12S,E)-9-benzyl-6-(4-fluorobenzyl)-2,2-dimethyl-4,7,10-trioxo-12-(((S)-2-oxopyrrolidin-3-yl)methyl)-3-oxa-5,8,11-triazapentadec-13-en-15-oate

References

1. Mondal S, et al. J Am Chem Soc. 2022 Nov 23;144(46):21035-21045.

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