Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : SM253
CAS No.: 1610546-52-5
Catalog No.: PC-60497Not For Human Use, Lab Use Only.
SM253 (SM 253, SM-253) is a novel potent Hsp90 inhibitor that does not induce heat shock response.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 1 mg | $288 | In stock | |
| 2 mg | $488 | In stock | |
| 5 mg | Get quote | ||
| 10 mg | Get quote | ||
| 25 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
SM253 (SM 253, SM-253) is a novel potent Hsp90 inhibitor that does not induce heat shock response.
SM253 demonstrates cytotoxicity to both HCT-116 and MiaPaCa-2 cells lines with IC50 of 5 and 5.5 uM, respectively.
SM253 also induces apoptosis and significantly increases caspase 3/7 activity compared to 17-AAG (2-fold); binds to the N-middle linker region of Hsp90, resulting in reduced client protein activation and preventing C-terminal co-chaperones and client proteins from binding to Hsp90.
SM253 exhibits antiproliferative and pro-apoptotic activity in multiple prostate cancer cell lines (LNCaP, 22Rv1, and PC-3) at low micromolar concentrations.
| M.Wt | 716.942 | |
| Formula | C39H52N6O5S | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
Soluble in 30%ACN/H2O |
|
| Chemical Name/SMILES |
(3R,6R,9R,12S,15S)-9-benzhydryl-3,12-diisobutyl-15-isopropyl-1-methyl-6-(thiazol-4-ylmethyl)-1,4,7,10,13-pentaazacyclopentadecane-2,5,8,11,14-pentaone |
|
1. Koay YC, et al. ACS Med Chem Lett. 2014 May 13;5(7):771-6.
2. Armstrong HK, et al. Prostate. 2016 Dec;76(16):1546-1559.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
