SM311 | LIMK1 inhibitor | Probechem Biochemicals

Chemical Structure : SM311

SM311 (SM-311)

Catalog No.: PC-26187Not For Human Use, Lab Use Only.

SM311 is a potent, selective, covalent LIMK1 inhibitor with EC50 of 45 nM in NanoBRET assays, 150-fold selective over LIMK2 isoform.

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Biological Activity

SM311 is a potent, selective, covalent LIMK1 inhibitor with EC50 of 45 nM in NanoBRET assays, 150-fold selective over LIMK2 isoform.
SM311 (100 nM) induces suppression of cofilin phosphorylation in LN229 glioblastoma cells.
SM311 displays excellent proteome-wide selectivity in pull-down assays.

Physicochemical Properties

M.Wt	431.46
Formula	C20H19F2N5O2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-(3-(difluoromethyl)-5-(2-isobutyramidothiazol-5-yl)-1H-pyrazol-1-yl)phenyl)acrylamide

References

1. Mandel S, et al. bioRxiv, 2025: 2025.04. 17.649341.

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SM311 (SM-311)

Biological Activity

Physicochemical Properties

References

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