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SMARt-420

Chemical Structure : SMARt-420

CAS No.: 1616242-21-7

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SMARt-420 (BDM 41420)

Catalog No.: PC-62330Not For Human Use, Lab Use Only.

SMARt-420 (BDM 41420) is a small molecule that can fully reverses ethionamide-acquired resistance and clears ethionamide-resistant M. tuberculosis infection in mice, also increases the basal sensitivity of bacteria to ethionamide.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    SMARt-420 (BDM 41420) is a small molecule that can fully reverses ethionamide-acquired resistance and clears ethionamide-resistant M. tuberculosis infection in mice, also increases the basal sensitivity of bacteria to ethionamide.

    Physicochemical Properties

    M.Wt 340.346
    Formula C17H19F3N2O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4,4,4-Trifluoro-1-(3-phenyl-1-oxa-2,8-diaza-spiro[4.5]dec-2-en-8-yl)-butan-1-one

    References

    1. Blondiaux N, et al. Science. 2017 Mar 17;355(6330):1206-1211.

    2. Wohlkönig A, et al. Biochem Biophys Res Commun. 2017 May 27;487(2):403-408.

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