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Chemical Structure : SMC18
Catalog No.: PC-21925Not For Human Use, Lab Use Only.
SMC18 is a specific small molecule CD47/SIRPα and PD-1/PD-L1 dual inhibitor, effectively blocks the CD47/SIRPα and PD-1/PD-L1 interactions with IC50 of 17.8 and 19.7 uM (human SIRPα and hPD-L1) respectively.
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SMC18 is a specific small molecule CD47/SIRPα and PD-1/PD-L1 dual inhibitor, effectively blocks the CD47/SIRPα and PD-1/PD-L1 interactions with IC50 of 17.8 and 19.7 uM (human SIRPα and hPD-L1) respectively.
SMC18 binds SIRPα and PD-L1 to block CD47/SIRPα and PD-1/PD-L1 interaction.
SMC18 does not impede the hTIGIT/hPVR, hLAG-3/hFGL-1, hCD112R/hCD112, and hTIM-3/hGal-9 pathways.
SMC18 effectively enhances the macrophages-mediated phagocytosis of tumor cells.
SMC18 effectively inhibits the phosphorylation of PD-1 and restores T cell function.
SMC18 (6 mg/kg) significantly inhibits MC38 tumor growth and triggers antitumor immune response, shows no hematotoxicity and hepatotoxicity.
SMC18 exhibits synergistic inhibition of MC38 tumor growth by combining with radiotherapy.
| M.Wt | 475.56 | |
| Formula | C26H25N3O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Jin S, et al. Cell Commun Signal. 2024 Mar 11;22(1):173.
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