SMER3

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Chemical Structure : SMER3

CAS No.: 67200-34-4

Catalog No.: PC-27693Not For Human Use, Lab Use Only.

SMER3 is a specific small molecule inhibitor of E3 ubiquitin ligase SCFMet30, a member of SCF family E3 ubiquitin ligases.

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Biological Activity

SMER3 is a specific small molecule inhibitor of E3 ubiquitin ligase SCFMet30, a member of SCF family E3 ubiquitin ligases.
SMER3 does not inhibit the closely related SCFCdc4.
SMER3 enhances rapamycin's growth inhibitory effect by inhibition of SCFMet30.
SMER3 prevents the assembly of SCFMet30 or induces SCF complex dissociation.
SMER3 directly binds to Met30-Skp1, but not Skp1 alone.
SMER3 specifically inactivates SCFMet30 by binding to Met30.

Physicochemical Properties

M.Wt	224.18
Formula	C11H4N4O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	9H-Indeno[1,2-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-one

References

1. Aghajan M, et al. Nat Biotechnol. 2010 Jul;28(7):738-42.

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SMER3

Biological Activity

Physicochemical Properties

References

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