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Chemical Structure : SMM-189
Catalog No.: PC-22115Not For Human Use, Lab Use Only.
SMM-189 is a selective cannabinoid receptor 2 (CB2) inverse agonist with Ki of 121.3 nM, 40-fold selective over CB1 receptor.
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SMM-189 is a selective cannabinoid receptor 2 (CB2) inverse agonist with Ki of 121.3 nM, 40-fold selective over CB1 receptor.
SMM-189 prevents the rat primary microglia-mediated inflammation and shows moderate neuroprotection against N-methyl-D-aspartic acid (NMDA) receptor-mediated excitotoxicity in rat primary hippocampal cultures containing both neurons and glia.
SMM-189 (6 mg/kg, i.p., b.i.d.) prevented the seizure-induced cytokine surge in the brain, neuronal death, and behavioral impairments 24 h after status epilepticus (SE).
SMM-189 shows potential for the treatment of neurodegenerative disorders and traumatic brain injury.
| M.Wt | 359.20 | |
| Formula | C19H12Cl2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Alghamdi SS, et al. Bioorg Med Chem. 2021 Mar 1;33:116035.
2. Yu Y, et al. Mol Neurobiol. 2020 Jun;57(6):2830-2845.
3. Presley C, et al. Pharmacol Res Perspect. 2015 Aug;3(4):e00159.
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