SMU-C409

Chemical Structure : SMU-C409

Catalog No.: PC-28204Not For Human Use, Lab Use Only.

SMU-C409 is a potent, specific small molecule TLR1/2 agonist with EC50 of 65 nM, activates TLR1/2, recruits MyD88, induces NF-κB phosphorylation, and stimulates TNF-α/IL-1β secretion, induces robust immune cell activation and antitumor immunomodulation.

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Biological Activity

SMU-C409 is a potent, specific small molecule TLR1/2 agonist with EC50 of 65 nM, activates TLR1/2, recruits MyD88, induces NF-κB phosphorylation, and stimulates TNF-α/IL-1β secretion, induces robust immune cell activation and antitumor immunomodulation.

Physicochemical Properties

M.Wt	395.54
Formula	C21H21N3OS2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	Thiourea, N-[5,6-dihydro-3-(2-methyl-1-oxopropyl)-4H-cyclopenta[b]thien-2-yl]-N′-5-quinolinyl-

References

1. Qiuyue Fu, et al. J Med Chem. 2025 Dec 25;68(24):26030-26048.

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SMU-C409

Biological Activity

Physicochemical Properties

References

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