Chemical Structure : SMU-C68
CAS No.:
2677039-75-5
SMU-C68
Catalog No.: PC-25125Not For Human Use, Lab Use Only.
SMU-C68 is a potent, selective human TLR1/2 agonist with EC50 of 9 nM in HEK-Blue hTLR2 cells, selectively targets the TLR1/2 heterodimer.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
SMU-C68 is a potent, selective human TLR1/2 agonist with EC50 of 9 nM in HEK-Blue hTLR2 cells, selectively targets the TLR1/2 heterodimer.
SMU-C68 shows negligible effect on the remaining TLR3, TLR4, TLR7, and TLR8 cells.
SMU-C68 exhibits strong binding to TLR2 with a KD of 49.8 nM.
SMU-C68 dose-dependently upregulates TLR2 expression in both HEK-Blue hTLR2 cells and THP-1 cells, and stimulates TNF-α secretion in wild-type THP-1 cells but not in TLR2-knockdown cells.
SMU-C68 specifically activates TLR1/2 heterodimer and recruits MyD88 to induce NF-κB downstream pathway.
SMU-C68 enhances TNF-α and IL-1β release in an NF-κB-dependent manner in human PBMCs.
SMU-C68 induces immune responses in co-culture system, induces apoptosis in SJSA-1 cells and SK-OV-3 cells after 24 h coculture with PMA-differentiated THP-1 cells.
Physicochemical Properties
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M.Wt
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411.54
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Formula
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C21H21N3O2S2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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Isopropyl 2-(3-(quinolin-5-yl)thioureido)-5,6-dihydro-4H-cyclopenta[b]thiophene-3- carboxylate
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References
1. Zeng X, et al. Eur J Med Chem. 2025 Jul 12;297:117968.
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