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SMU-C80

Chemical Structure : SMU-C80

CAS No.: 2649309-05-5

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SMU-C80

Catalog No.: PC-25128Not For Human Use, Lab Use Only.

SMU-C80 is a highly efficient and specific human TLR1/2 agonist, effectively promotes the SEAP signals in HEK-Blue hTLR2 cells with EC50 of 31.02 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

SMU-C80 is a highly efficient and specific human TLR1/2 agonist, effectively promotes the SEAP signals in HEK-Blue hTLR2 cells with EC50 of 31.02 nM.
SMU-C80 shows negligible activation in other HEK-Blue hTLRs.
SMU-C80 recruits the adaptor protein MyD88 and triggers the NF-κB pathway to release cytokines such as TNF-α and IL-1β from human, but not murine, cells.
SMU-C80 increases the percentage of T, B, and NK cells ex vivo and activated the immune cells, which suppressed cancer cell growth in vitro.

Physicochemical Properties

M.Wt 428.54
Formula C22H21FN2O2S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Isopropyl 2-(3-(4-Fluoronaphthalen-1-yl)thioureido)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate

References

1. Chen Z, et al. J Med Chem. 2021 Jun 10;64(11):7371-7389.

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