Chemical Structure : SMU-CX1
CAS No.:
10371-86-5
SMU-CX1
(NSC69187)
Catalog No.: PC-25126Not For Human Use, Lab Use Only.
SMU-CX1 is a specific TLR3 inhibitor, inhibits TLR3-mediated SEAP signaling with IC50 of 0.11 uM, inhibits influenza A virus (IAV) and SARS-CoV-2 activity.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
SMU-CX1 is a specific TLR3 inhibitor, inhibits TLR3-mediated SEAP signaling with IC50 of 0.11 uM, inhibits influenza A virus (IAV) and SARS-CoV-2 activity.
SMU-CX1 selectively inhibits TLR3-activated NO signals but not that of other homologous TLRs.
SMU-CX1 significantly reduces the expression of inflammatory factors downstream of TLR3 signaling pathway induced by IAV stimulation.
SMU-CX1 inhibits SARS-CoV-2 in Vero-E6 cells with IC50 of 0.43 uM.
MU-CX1 exhibits good inhibitory activity against influenza A virus with IC50 ranged from 0.14 to 0.33 µM.
SMU-CX1 significantly inhibits PB2 and NP protein of IAV, can also inhibit inflammatory factors in host cells including IFN-β, IP-10 and CCL-5.
Physicochemical Properties
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M.Wt
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276.34
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Formula
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C18H16N2O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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9-Methoxy-5,11-dimethyl-6H-pyrido[4,3-b]carbazole
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References
1. Yue Pan, et al. Bioorg Med Chem Lett. 2024 Mar 15:101:129672.
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