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Chemical Structure : SN-011
CAS No.: 2249435-90-1
Catalog No.: PC-38078Not For Human Use, Lab Use Only.
SN-011 (SN011) is a potent, selective STING antagonist with IC50 of 76 nM (STING signaling inhibition).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $228 | In stock | |
| 50 mg | $398 | In stock | |
| 100 mg | $698 | In stock | |
| 500 mg | $1380 | In stock | |
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SN-011 (SN011) is a potent, selective STING antagonist with IC50 of 76 nM (STING signaling inhibition).
SN-011 binds with higher affinity (Kd=4.03 nM) to the cyclic dinucleotide (CDN)-binding pocket of STING than endogenous 2'3'-cGAMP (Kd=9.23 nM).
SN-011 (1 μM) significantly suppresses the induction of Ifnb, Cxcl10, and Il6 mRNA in MEFs activated by various canonical STING stimulators (ISD, HT-DNA, HSV-1, c-di-GMP, and 2′3′-cGAMP).
SN-011 specifically inhibits STING activation and STING-dependent signaling.
SN-011 suppresses systemic inflammation and death in Trex1−/− mice.
| M.Wt | 462.495 | |
| Formula | C25H19FN2O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-(3-((4-fluorophenyl)sulfonamido)-4-hydroxyphenyl)-[1,1'-biphenyl]-4-carboxamide |
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1. Hong Z, et al. Proc Natl Acad Sci U S A. 2021 Jun 15;118(24):e2105465118.
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