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Chemical Structure : SN79
Catalog No.: PC-60749Not For Human Use, Lab Use Only.
SN79 is a potent, orally active sigma receptor antagonist with Ki of 27 and 7 nM for σ1 and σ2, respectively.
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SN79 is a potent, orally active sigma receptor antagonist with Ki of 27 and 7 nM for σ1 and σ2, respectively.
SN79 also exhibits moderate affinity for serotonin transporters and norepinephrine transporters, displays a moderate affinity for 5-HT2 receptors and negligible affinity, does not inhibit major cytochrome P450 enzymes.
SN79 significantly attenuates cocaine-induced convulsions and locomotor activity in mice, also significantly attenuates the development and expression of the sensitized response to repeated cocaine exposures.
| M.Wt | 411.477 | |
| Formula | C23H26FN3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kaushal N, et al. AAPS J. 2011 Sep;13(3):336-46.
2. Seminerio MJ, et al. Eur J Pharmacol. 2012 Sep 15;691(1-3):103-9.
3. Kaushal N, et al. Eur Neuropsychopharmacol. 2013 Aug;23(8):960-71.
4. Kaushal N, et al. Eur J Pharmacol. 2014 Feb 5;724:193-203.
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