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Chemical Structure : SN79 dihydrochloride
Catalog No.: PC-35890Not For Human Use, Lab Use Only.
SN79 dihydrochloride (Sigma receptor ligand SN79) is a putative sigma receptor (σ receptor) antagonist with nanomolar affinity and selectivity for σ receptors over 57 other binding sites.
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SN79 dihydrochloride (Sigma receptor ligand SN79) is a putative sigma receptor (σ receptor) antagonist with nanomolar affinity and selectivity for σ receptors over 57 other binding sites.
SN79 shows activity against methamphetamine-induced neurotoxicity in vivo.
SN79 blocks methamphetamine-induced microglial activation and cytokine upregulation.
| M.Wt | 484.393 | |
| Formula | C23H28Cl2FN3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Nicholson HE, et al. J Pharmacol Exp Ther. 2018 Dec 7. pii: jpet.118.253484. doi: 10.1124/jpet.118.253484.
2. Kaushal N, et al. AAPS J. 2011 Sep;13(3):336-46. doi: 10.1208/s12248-011-9274-9.
3. Seminerio MJ, et al. Eur J Pharmacol. 2012 Sep 15;691(1-3):103-9. doi: 10.1016/j.ejphar.2012.07.029.
4. Kaushal N, et al. Eur J Pharmacol. 2014 Feb 5;724:193-203.
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