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Chemical Structure : SNS-314
CAS No.: 1146618-41-8
Catalog No.: PC-42820Not For Human Use, Lab Use Only.
SNS-314 is a potent, selective pan-Aurora kinase inhibitor with IC50 of 9 and 31 nM for Aurora A and Aurora B, repectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $78 | In stock | |
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | $528 | In stock | |
| 250 mg | Get quote |
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SNS-314 is a potent, selective pan-Aurora kinase inhibitor with IC50 of 9 and 31 nM for Aurora A and Aurora B, repectively.
SNS-314 demonstrates broad activity in vitro against multiple human cancer cell lines and exhibits significant in vivo activity against a wide range of tumor xenograft models.
SNS-314 shows additive antiproliferative effects with carboplatin, gemcitabine, 5-FU, daunomycin, and SN-38 both in vitro and in vivo.
| M.Wt | 527.04 | |
| Formula | C19H19ClN6O4S3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Urea, N-(3-chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]-, methanesulfonate (1:1) |
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1. Oslob JD, et al. Bioorg Med Chem Lett. 2008 Sep 1;18(17):4880-4.
2. VanderPorten EC, et al. Mol Cancer Ther. 2009 Apr;8(4):930-9.
3. Arbitrario JP, et al. Cancer Chemother Pharmacol. 2010 Mar;65(4):707-17.
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