SNX9-1-20

Chemical Structure : SNX9-1-20

Catalog No.: PC-25578Not For Human Use, Lab Use Only.

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Biological Activity

SNX9-1-20 is a potent, specific cyclin-dependent kinase 3 (CDK3) inhibitor with IC50 of 164 nM, inhibits CDK3/Cyclin E with IC50 of 0.47 uM (Rb-CTF) and 0.77 uM (Histone H1), highly selective over CDK2 (>50-fold).
SNX9-1-20 is potent in preventing the induction of transcription by p21 (IC50=5.1 uM) and growth inhibition of the HT1080-based reporter cell line (IC50=2.5 uM).

Physicochemical Properties

M.Wt	243.13
Formula	C11H12Cl2N2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(5,7-dichloro-2-methyl-1H-indol-3-yl)ethan-1-amine

References

1. Patent WO2014089450 A1.

2. Theodosia Teo, et al. Pharmacol Res. 2022 Jun:180:106249.

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SNX9-1-20

Biological Activity

Physicochemical Properties

References

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