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Chemical Structure : SP2509
CAS No.: 1423715-09-6
Catalog No.: PC-43122Not For Human Use, Lab Use Only.
SP2509 is a potent, selective histone demethylase LSD1 (KDM1A) inhibitor with IC50 of 13 nM, shows no activity against MAOA, MAOB, LDH and glucose oxidase.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $198 | In stock | |
| 100 mg | $488 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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SP2509 is a potent, selective histone demethylase LSD1 (KDM1A) inhibitor with IC50 of 13 nM, shows no activity against MAOA, MAOB, LDH and glucose oxidase.
SP2509 inhibits the colony growth of OCI-AML3 significantly more than of the other AML cell-types, induces more apoptosis of AML cells expressing mutant NPM1 than mixed-lineage leukemia fusion oncoproteins.
SP2509 significantly improves the survival of immune-depleted mice model of AML.
SP2509 is synergistically lethal against cultured and primary AML blasts combined with panobinostat.
| M.Wt | 437.8972 | |
| Formula | C19H20ClN3O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 33 mg/mL |
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| Chemical Name/SMILES |
Benzoic acid, 3-(4-morpholinylsulfonyl)-, (2E)-2-[1-(5-chloro-2-hydroxyphenyl)ethylidene]hydrazide |
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1. Fiskus W, et al. Leukemia. 2014 Nov;28(11):2155-64.
2. Sonnemann J, et al. Br J Haematol. 2017 Dec 3. doi: 10.1111/bjh.14983.
3. Sehrawat A, et al. Proc Natl Acad Sci U S A. 2018 Mar 26. pii: 201719168.
4. Khanal T, et al. Sci Rep. 2017 Sep 6;7(1):10662.
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