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Chemical Structure : SPOP-IN-6b
Catalog No.: PC-61735Not For Human Use, Lab Use Only.
SPOP-IN-6b is a potent, small-molecule E3 Ligase adaptor SPOP (speckle-type POZ protein) inhibitor that inhibits the SPOP-substrate protein interaction with IC50 of 35 uM (inhibits puc-SBC1 peptide binding to SPOP).
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SPOP-IN-6b is a potent, small-molecule E3 Ligase adaptor SPOP (speckle-type POZ protein) inhibitor that inhibits the SPOP-substrate protein interaction with IC50 of 35 uM (inhibits puc-SBC1 peptide binding to SPOP); suppresses oncogenic SPOP-signaling pathways, and kills human ccRCC cells that are dependent on oncogenic cytoplasmic SPOP.
| M.Wt | 500.603 | |
| Formula | C28H32N6O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Guo ZQ, et al. Cancer Cell. 2016 Sep 12;30(3):474-484.
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