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Chemical Structure : SR-717
CAS No.: 2375421-09-1
Catalog No.: PC-38087Not For Human Use, Lab Use Only.
SR-717 (SR717) is a non-nucleotide, small-molecule STING agonist, demonstrates broad interspecies and interallelic specificity with EC50 of 2.1 uM and 2.2 uM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $198 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | $548 | In stock | |
| 500 mg | $988 | In stock | |
| 1 g | Get quote |
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SR-717 (SR717) is a non-nucleotide, small-molecule STING agonist, demonstrates broad interspecies and interallelic specificity with EC50 of 2.1 uM and 2.2 uM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines.
SR-717 functions as a direct cGAMP mimetic that induces the same "closed" conformation of STING.
SR-717 displays antitumor activity, promotes the activation of CD8+ T, natural killer, and dendritic cells in relevant tissues, and facilitates antigen cross-priming.
SR-717 induces the expression of clinically relevant targets, including PD-L1, in a STING-dependent manner.
| M.Wt | 351.198 | |
| Formula | C15H8F2LiN5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
lithium 2-(6-(1H-imidazol-1-yl)pyridazine-3-carboxamido)-4,5-difluorobenzoate |
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1. Chin EN, et al. Science. 2020 Aug 21;369(6506):993-999.
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