Catalog No.: PC-24369Not For Human Use, Lab Use Only.
SR1078 a selective synthetic RORα/RORγ agonist / ligand, directly binds to the ligand binding domain of RORα and RORγ, increases the transcriptional activity.
SR1078 a selective synthetic RORα/RORγ agonist / ligand, directly binds to the ligand binding domain of RORα and RORγ, increases the transcriptional activity. SR1078 significantly inhibits the constitutive transactivation activity of RORα and RORγ, but has no effect on the activity of FXR, LXRα and LXRβ, in a cell-based chimeric receptor Gal4 DNA-binding domain – NR ligand binding domain cotransfection assay. SR1078 dose-dependently activates RORα and RORγ in HepG2 cells that express both RORα and RORγ. SR1078 activates ROR target gene transcription both in vitro and in vivo.
