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Chemical Structure : SR12813
CAS No.: 126411-39-0
Catalog No.: PC-42261Not For Human Use, Lab Use Only.
SR12813 (GW485801) is potent and efficacious pregnane X receptor (PXR) activator with EC50 of 200 and 700 nM for human and rabbit PXR, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | Get quote |
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SR12813 (GW485801) is potent and efficacious pregnane X receptor (PXR) activator with EC50 of 200 and 700 nM for human and rabbit PXR, respectively.
SR12813 (GW485801) only shows weak activition for rat and mouse PXR.
SR12813 (GW485801) inhibits cholesterol synthesis (IC50=1.2 uM) with no effect on fatty acid synthesis, reduces cellular HMG-CoA reductase activity with IC50 of 0.85 uM.
SR12813 (GW485801) induce CYP3A expression in primary hepatocytes.
| M.Wt | 504.5336 | |
| Formula | C24H42O7P2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Phosphonic acid, P,P'-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]ethenylidene]bis-, P,P,P',P'-tetraethyl ester |
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1. Jones SA, et al. Mol Endocrinol. 2000 Jan;14(1):27-39.
2. Berkhout TA, et al. J Biol Chem. 1996 Jun 14;271(24):14376-82.
3. Watkins RE, et al. Science. 2001 Jun 22;292(5525):2329-33.
4. Berkhout TA, et al. Atherosclerosis. 1997 Sep;133(2):203-12.
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