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Chemical Structure : SR1555
CAS No.: 1386439-51-5
Catalog No.: PC-35084Not For Human Use, Lab Use Only.
SR1555 is a selective RORγ inverse agonist (IC50=1.5 uM) that suppresses T(H)17 cells and stimulates T regulatory cells.
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SR1555 is a selective RORγ inverse agonist (IC50=1.5 uM) that suppresses T(H)17 cells and stimulates T regulatory cells.
SR1555 is devoid of LXR, FXR, and RORα activity, displaces [3H]T0901317 from the ligand binding domain (LBD) of RORγ with IC50 of 1 uM.
SR1555 represses the expression of RORγ while leading to increased expression of FGF21 and adipoQ in pre-adipocyctes.
SR1555 inhibits activation of hormone-sensitive lipase and increased fatty acid oxidation in obese diabetic mice.
| M.Wt | 460.42 | |
| Formula | C22H22F6N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-(4-((4'-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-[1,1'-biphenyl]-4-yl)methyl)piperazin-1-yl)ethanone |
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1. Chang MR, et al. Mol Pharmacol. 2015 Jul;88(1):48-56.
2. Solt LA, et al. ACS Chem Biol. 2012 Sep 21;7(9):1515-9.
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