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Chemical Structure : SR2211
CAS No.: 1359164-11-6
Catalog No.: PC-35405Not For Human Use, Lab Use Only.
SR2211 (SR-2211) is a potent, selective RORγ inverse agonist (Ki=105 nM, IC50=320 nM) that potently inhibits production of IL-17 in cells.
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|---|---|---|---|
| 5 mg | $198 | In stock | |
| 10 mg | $298 | In stock | |
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| 50 mg | Get quote | ||
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SR2211 (SR-2211) is a potent, selective RORγ inverse agonist (Ki=105 nM, IC50=320 nM) that potently inhibits production of IL-17 in cells.
SR2211 displays weak activity for LXRα, has no impact on the transcriptional activity of RORα and FXR.
SR2211 modulates the expression of IL 17A and IL-23R in EL-4 cells, significantly decreases IL-17A and IL-17F production in the BT co-culture system at 0.37-10 uM.
SR2211 reduces inflammatory cytokine production in LPS-stimulated RAW 264.7 cells, suppresses joint inflammation in the CIA experimental model.
| M.Wt | 527.487 | |
| Formula | C26H24F7N3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1,1,1,3,3,3-hexafluoro-2-(2-fluoro-4'-((4-(pyridin-4-ylmethyl)piperazin-1-yl)methyl)-[1,1'-biphenyl]-4-yl)propan-2-ol |
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1. Kumar N, et al. ACS Chem Biol. 2012 Apr 20;7(4):672-7.
2. Melton AC, et al. PLoS One. 2013;8(3):e58966.
3. Chang MR, et al. Arthritis Rheumatol. 2014 Mar;66(3):579-88.
4. Wang J, et al. Nat Med. 2016 May;22(5):488-96.
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