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Chemical Structure : SR7826
CAS No.: 1219728-20-7
Catalog No.: PC-35194Not For Human Use, Lab Use Only.
SR7826 is a potent and selective LIM kinase (LIMK) inhibitor with IC50 of 43 nM (LIMK1), displays >100-fold selectivity over ROCK1 and ROCK2, as well as JNK kinases (>400-fold).
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|---|---|---|---|
| 5 mg | $188 | In stock | |
| 10 mg | $318 | In stock | |
| 25 mg | $528 | In stock | |
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| 100 mg | Get quote |
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SR7826 is a potent and selective LIM kinase (LIMK) inhibitor with IC50 of 43 nM (LIMK1), displays >100-fold selectivity over ROCK1 and ROCK2, as well as JNK kinases (>400-fold).
SR7826 inhibits only Limk1 and STK16 with >80% inhibition at 1 uM in a panel of 61 kinases.
SR7826 potently inhibits cofilin phosphorylation in A7r5, PC-3, and CEM-SS T cells (IC50 <1 uM), suppresses migration and invasion of PC-3 cells in vitro.
| M.Wt | 387.43 | |
| Formula | C22H21N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-(2-Hydroxyethyl)-N'-[4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-N-phenylurea |
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1. Yu Q, et al. Br J Pharmacol. 2018 Jun;175(11):2077-2096.
2. Yin Y, et al. J Med Chem. 2015 Feb 26;58(4):1846-61.
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