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Chemical Structure : SR9011 hydrochloride
CAS No.: 2070014-94-5
Catalog No.: PC-45117Not For Human Use, Lab Use Only.
SR9011 hydrochloride is a potent, small molecule nuclear receptors REV-ERBα/β agonist with IC50 of 670/800 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $158 | In stock | |
| 10 mg | $248 | In stock | |
| 25 mg | $398 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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SR9011 hydrochloride is a potent, small molecule nuclear receptors REV-ERBα/β agonist with IC50 of 670/800 nM, respectively.
SR9011 potently and efficaciously suppresses transcription in a cotransfection assay using full-length REV-ERBα along with a luciferase reporter driven by the Bmal1 promoter (IC50=710 nM).
SR9011 decreases obesity by reducing fat mass and markedly improves dyslipidaemia and hyperglycaemia in diet-induced obese mice.
| M.Wt | 515.4962 | |
| Formula | C23H32Cl2N4O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 32 mg/mL |
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| Chemical Name/SMILES |
1-Pyrrolidinecarboxamide, 3-[[[(4-chlorophenyl)methyl][(5-nitro-2-thienyl)methyl]amino]methyl]-N-pentyl-,hydrochloride |
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1. Solt LA, et al. Nature. 2012 Mar 29;485(7396):62-8.
2. Banerjee S, et al. Nat Commun. 2014 Dec 23;5:5759.
3. Alibhai FJ, et al. J Mol Cell Cardiol. 2017 Apr;105:24-37.
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