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Chemical Structure : SRI-37264
Catalog No.: PC-38203Not For Human Use, Lab Use Only.
SRI-37264 (SRI 37264) is a small molecule inhibitor of HIV-1 Nef-mediated activation of the myeloid Src-family kinase Hck, blocks HIV-1 replication in macrophages and disrupts MHC-I downregulation.
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SRI-37264 (SRI 37264) is a small molecule inhibitor of HIV-1 Nef-mediated activation of the myeloid Src-family kinase Hck, blocks HIV-1 replication in macrophages and disrupts MHC-I downregulation.
SRI-37264 bound directly to recombinant Nef by surface plasmon resonance (SPR) in vitro.
SRI-37264 inhibited HIV-1 replication in primary macrophages in the 0.04 to 5 μM range without cytotoxicity.
| M.Wt | 375.827 | |
| Formula | C17H14ClN3O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Lori A Emert-Sedlak, et al. ACS Infect Dis. 2022 Jan 14;8(1):91-105.
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