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Chemical Structure : SRJ-23
Catalog No.: PC-70353Not For Human Use, Lab Use Only.
A novel semisynthetic derivative of andrographolide that directly target Ras to block the exchange of GDP for GTP and thus prevent Ras activation.
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A novel semisynthetic derivative of andrographolide that directly target Ras to block the exchange of GDP for GTP and thus prevent Ras activation; significantly suppresses K-Ras GTP loading, whereas H-Ras and N-Ras GTP loading are much less sensitive; reduceds K-RasG12V GTP, phosphorylated ERK (ppERK) levels in K-RasG12V-transformed cells; induces G1 arrest and apoptosis in MCF-7 and HCT-116 cells, respectively.
| M.Wt | 317.704 | |
| Formula | C15H9ClFN3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Hocker HJ, et al. Proc Natl Acad Sci U S A. 2013 Jun 18;110(25):10201-6.
2. Jada SR, et al. Br J Pharmacol. 2008 Nov;155(5):641-54.
3. Wong HC, et al. Cell Biol Toxicol. 2014 Oct;30(5):269-88.
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