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Chemical Structure : SS-4
Catalog No.: PC-72849Not For Human Use, Lab Use Only.
SS-4 is a highly selective small molecule inhibitor of STAT3 tyrosine phosphorylation that potently inhibits GBM tumorigenesis in vitro and in vivo.
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SS-4 (STAT3 inhibitor SS-4) is a highly selective small molecule inhibitor of STAT3 tyrosine phosphorylation that potently inhibits GBM tumorigenesis in vitro and in vivo.
SS-4 strongly and selectively inhibits STAT3 Y-705 phosphorylation in MT330 and LN229 GBM cells and inhibits their proliferation and inducs apoptosis with an IC50 of 100 nM.
SS-4 increases the expression of STAT3 repressed genes, while decreasing the expression of STAT3 promoted genes.
SS-4 markedly reduces the growth of GBM intracranial tumor xenografts.
| M.Wt | 348.42 | |
| Formula | C20H16N2O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Yinan Wang, et al. Cancer Lett. 2022 Mar 1;533:215614.
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