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Chemical Structure : SSYA 10-001
CAS No.: 675104-49-1
Catalog No.: PC-72800Not For Human Use, Lab Use Only.
SSYA 10-001 (DSHS00884, SSYA10-001) is a small molecule inhibitor of SARS-CoV-2 Nsp13 helicase with IC50 of 3.5 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $278 | In stock | |
| 10 mg | $458 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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SSYA 10-001 (DSHS00884, SSYA10-001) is a small molecule inhibitor of SARS-CoV-2 Nsp13 helicase with IC50 of 3.5 uM.
SSYA 10-001 specifically blocks the double-stranded RNA (dsRNA) and dsDNA unwinding activities of nsp13 with IC50 of 5.70 and 5.30 uM, respectively.
SSYA 10-001 also has inhibitory activity (50% effective concentration [EC(50)] = 8.95 μM) in a SARS-CoV replicon assay, with low cytotoxicity.
SSYA10-001 does not affect ATP hydrolysis or nsp13 binding to the nucleic acid substrate.
SSYA10-001 did not inhibit hepatitis C virus (HCV) helicase, other bacterial and viral RNA-dependent RNA polymerases, or reverse transcriptase.
SSYA10-001 also inhibits replication of two other coronaviruses, mouse hepatitis virus (MHV) and Middle Eastern respiratory syndrome coronavirus (MERS-CoV).
| M.Wt | 308.37 | |
| Formula | C12H12N4O2S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2,4-dihydro-5-[[(2-nitrophenyl)thio]methyl]-4-(2-propen-1-yl)-3H-1,2,4-triazole-3-thione |
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1. Adedeji AO, et al. Antimicrob Agents Chemother. 2012 Sep;56(9):4718-28.
2. Adedeji AO, et al. Antimicrob Agents Chemother. 2014 Aug;58(8):4894-8.
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