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Chemical Structure : ST-162
Catalog No.: PC-61742Not For Human Use, Lab Use Only.
ST-162 is a potent, bifunctional MAPK/PI3K antagonist with IC50 of 191 nM and 398 nM for PI3Kα and MEK1, respectively.
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ST-162 is a potent, bifunctional MAPK/PI3K antagonist with IC50 of 191 nM and 398 nM for PI3Kα and MEK1, respectively.
ST-162 produces regression of mutant KRAS or BRAF addicted xenograft models of colorectal cancer and melanoma and stasis of BRAF/PTEN mutant melanomas.
ST-162 increases efficacy in a syngeneic KRAS mutant colorectal cancer model combined with checkpoint blocker PD-L1.
| M.Wt | 982.752 | |
| Formula | C40H44F5IN10O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Galbán S, et al. Mol Cancer Ther. 2017 Nov;16(11):2340-2350.
2. Van Dort ME, et al. J Med Chem. 2016 Mar 24;59(6):2512-22.
3. Van Dort ME, et al. ACS Med Chem Lett. 2017 Jul 24;8(8):808-813.
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