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Chemical Structure : ST-168
Catalog No.: PC-61741Not For Human Use, Lab Use Only.
ST-168 is a novel potent, orally available MEK/PI3K bifunctional inhibitor with IC50 of 182, 69.2, 1482, 2293, and 41.7 nM for MEK1, PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ, respectively.
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ST-168 is a novel potent, orally available MEK/PI3K bifunctional inhibitor with IC50 of 182, 69.2, 1482, 2293, and 41.7 nM for MEK1, PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ, respectively.
ST-168 exhibits improved inhibition toward PI3K isoforms compared to ST-162.
ST-168 demonstrates superior tumoricidal efficacy over ST-162 in an A375 melanoma spheroid tumor model.
| M.Wt | 1010.762 | |
| Formula | C41H44F5IN10O7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Van Dort ME, et al. ACS Med Chem Lett. 2017 Jul 24;8(8):808-813.
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