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Chemical Structure : STA-1474
Catalog No.: PC-20709Not For Human Use, Lab Use Only.
STA-1474 is a water soluble prodrug of Ganetespib (STA 9090), which is a potent, second generation small-molecule inhibitor of HSP90 (IC50=4 nM).
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STA-1474 is a water soluble prodrug of Ganetespib (STA 9090), which is a potent, second generation small-molecule inhibitor of HSP90 (IC50=4 nM).
STA-1474 promoted loss of cell viability, inhibition of cell proliferation and induction of apoptosis in osteosarcoma (OSA) cell lines.
STA-1474 and its active metabolite STA-9090 also demonstrated increased potency compared to 17-AAG.
STA-1474 exhibited selectivity for OSA cells versus normal canine osteoblasts, and HSP90 co-precipitated with co-chaperones p23 and Hop in canine OSA cells but not in normal canine osteoblasts.
STA-1474 downregulated the expression of p-Met/Met, p-Akt/Akt and p-STAT3.
STA-1474 induced tumor regression, caspase-3 activation and downregulation of p-Met/Met and p-Akt/Akt in OSA xenografts.
| M.Wt | 444.38 | |
| Formula | C20H21N4O6P | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Lin TY, et al. Exp Hematol. 2008 Oct;36(10):1266-77.
2. McCleese JK, et al. Int J Cancer. 2009 Dec 15;125(12):2792-801.
3. Bansal H, et al. Blood. 2010 Nov 25;116(22):4591-9.
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