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Chemical Structure : STA-21
CAS No.: 28882-53-3
Catalog No.: PC-70249Not For Human Use, Lab Use Only.
STA-21 (NSC 628869, Ochromycinone) is a small-molecule inhibitor of STAT3, inhibits Stat3 DNA binding activity, Stat3 dimerization, and Stat3-dependent luciferase activity (20-30 uM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg | $228 | In stock | |
| 5 mg | $358 | In stock | |
| 10 mg | $558 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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STA-21 (NSC 628869, Ochromycinone) is a small-molecule inhibitor of STAT3, inhibits Stat3 DNA binding activity, Stat3 dimerization, and Stat3-dependent luciferase activity (20-30 uM).
STA-21 reduces the survival of breast carcinoma cells with constitutive Stat3 signaling.
STA-21 inhibits cell viability and growth and induces apoptosis through caspases 3, 8 and 9 pathways in human sarcoma cell lines.
| M.Wt | 306.3 | |
| Formula | C19H14O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(3S)-3,4-dihydro-8-hydroxy-3-methyl-benz[a]anthracene-1,7,12(2H)-trione |
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1. Song H, et al. Proc Natl Acad Sci U S A. 2005 Mar 29;102(13):4700-5.
2. Chen CL, et al. BMC Cancer. 2007 Jun 28;7:111.
3. Fuh B, et al. Br J Cancer. 2009 Jan 13;100(1):106-12.
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