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Chemical Structure : STAT3 inhibitor C188
CAS No.: 823828-18-8
Catalog No.: PC-60904Not For Human Use, Lab Use Only.
STAT3 inhibitor C188 (CPD188) is a potent, selective STAT3 inhibitor that blocks STAT3 binding to its phosphopeptide ligand (IC50=20 uM) and inhibits IL-6-mediated phosphorylation of STAT3.
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|---|---|---|---|
| 2 mg | $158 | In stock | |
| 5 mg | $248 | In stock | |
| 10 mg | $388 | In stock | |
| 25 mg | $598 | In stock | |
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STAT3 inhibitor C188 (CPD188) is a potent, selective STAT3 inhibitor that blocks STAT3 binding to its phosphopeptide ligand (IC50=20 uM) and inhibits IL-6-mediated phosphorylation of STAT3.
C188 inhibits nuclear translocation of phosphorylated Stat3 with IC50 of 39 uM.
C188 induces apoptosis preferentially of breast cancer cell lines with constitutive Stat3 activation.
| M.Wt | 433.449 | |
| Formula | C19H15NO7S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-(N-(3-((carboxymethyl)thio)-4-hydroxynaphthalen-1-yl)sulfamoyl)benzoic acid |
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1. Xu X, et al. PLoS One. 2009;4(3):e4783.
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