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Chemical Structure : STAT3 inhibitor DG-4
Catalog No.: PC-20605Not For Human Use, Lab Use Only.
DG-4 is a potent, selective inhibitor of STAT3-dependent transcription with IC50 of 0.12 uM in IL6-STAT3 luciferase reporter assays, 44-fold selectivity over IFN-γ STAT1.
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DG-4 is a potent, selective inhibitor of STAT3-dependent transcription with IC50 of 0.12 uM in IL6-STAT3 luciferase reporter assays, 44-fold selectivity over IFN-γ STAT1.
DG-4 does not bind to cellular STAT3 but to another prominent anticancer drug target, TrxR1.
DG-4 inhibits TrxR1 activity and contribute to TrxR1 inhibitory effects in cells at 1 uM.
DG-4 induces oxidative stress leading to Prx2/STAT3 oxidation, subsequently blocks STAT3-dependent transcription and induces cell death.
| M.Wt | 395.28 | |
| Formula | C18H20Cl2N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. S Busker, et al. Sci Adv. 2020 Mar 20;6(12):eaax7945.
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