Catalog No.: PC-22439Not For Human Use, Lab Use Only.
STING degrader AK59 (AK59-51TB) is a small molecule STING degrader leveraging HECT-domain E3 ligase HERC4, inhibits the cGAS/STING pathway via degradation of STING by proteasomal degradation.
STING degrader AK59 (AK59-51TB) is a small molecule STING degrader leveraging HECT-domain E3 ligase HERC4, inhibits the cGAS/STING pathway via degradation of STING by proteasomal degradation.
AK59-51TB able to induce the degradation of STING-SAVI mutants, induces STING degradation in CD14+ human PBMCs.
AK59-mediated STING degradation acts through the UPS involving HERC4, UBA5, and UBA6 as regulatory factors.
AK59 degrades STING by inducing its interaction with the E3 ligase HERC4.
